With the corruption in Despotism, your first city location can make the difference of fast or slow science development.
Yes, MWHC is right on target when he says he monitors the top 5 cities to see how others are doing
Anytime you decide to search for a better location, you are taking a chance. If you don't find one, you are in serious trouble.
Nothing worse than searching for a while, and finding out your best place is where you started.
But I will always gamble to see if I can find a trade special resource. And sometimes, it is the wrong decision