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Old October 18, 2003, 02:33   #1
st_swithin
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WARNING: Insomniacs beware!!
OH GOD NO!! SAY IT ISN'T SO!! Maybe I really AM dying. Screw this health crap, I'm getting some more coffee.

http://www.canoe.ca/Health9905/26_insomnia.html

Researchers discover new form of fatal insomnia
By KATHARINE WEBSTER -- The Associated Press

Canada Health Profile

Researchers have discovered a brain-wasting disease that begins with severe insomnia and ends in hallucinations and death.

The disease, sporadic fatal insomnia, is caused by the same type of deformed proteins, known as prions, that cause mad cow disease and its human variant, Creutzfeldt-Jakob disease, according to two studies.

There is no known treatment or cure. It is not clear what causes the disease, but scientists know it is not inherited. And unlike one type of Creutzfeldt-Jakob disease, it is not believed to come from infected meat.

Instead, scientists suspect it is caused by a spontaneous mutation in a single brain or nerve cell.

So far, they have identified only six cases of the disease, but there could be others that were misdiagnosed as other mind-destroying illnesses such as Alzheimer's disease.

Prions are proteins with Jekyll-and-Hyde personalities that cluster in the brain. When their molecules are folded into the correct shape, prions are benign, though no one knows their function.

Folded the wrong way, prions induce other proteins to mimic them. The misfolded prions then accumulate in parts of the brain, causing the tissue to break down and become full of holes, like a sponge.

Different prion diseases attack different parts of the brain, causing characteristic types of dementia and death.

Some are infectious, like mad cow disease in cattle and scrapie in sheep and goats. In humans, prion diseases are either inherited, caught from eating contaminated meat, or spontaneous.

Researchers have previously identified an inherited prion disorder whose main symptom is sleeplessness, called fatal familial insomnia.

In a case outlined in Thursday's New England Journal of Medicine, a 44-year-old patient had all the symptoms of the inherited disease, including prions with the same "signature," but without the inherited mutation. The case was reported by Dr. James Mastrianni, a neurologist at the University of Chicago.

The spontaneous, or sporadic, versions of the prion diseases are rare, but more common than their inherited counterparts.

Prions are still controversial. Some researchers believe it is impossible for proteins to replicate and cause disease, since they do not contain genetic material. These researchers believe the diseases are instead caused by as-yet-undiscovered viruses.

However, the new studies add to evidence the infection is caused by the abnormal shape of the prions, not another agent, Drs. Pierluigi Gambetti and Piero Parchi of Case Western Reserve University said in an accompanying editorial.

Gambetti and Parchi have described five similar cases of non-inherited fatal insomnia in a study scheduled to appear in the journal Neurology.
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Old October 18, 2003, 04:43   #2
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Does this mean that Apolyton is going to become practically deserted?
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Old October 18, 2003, 04:50   #3
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Old October 18, 2003, 05:41   #4
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I'll have a hard time getting to sleep tonight after reading that.

Wait a minute...
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Old October 18, 2003, 05:43   #5
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how the **** is this infectious?
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Old October 18, 2003, 07:02   #6
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If a mutuated prion comes into contact with an unmutated prion, it causes the unmutated prion to mutate. Thus, if you somehow get mutated prions from something into your brain, your prions will mutate.
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Old October 18, 2003, 07:07   #7
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It doesn't mutate, but it will change its shape into the "bad" form. This one will do the same to the next prion it meets, and so on.
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Old October 18, 2003, 11:19   #8
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We know why you posted this...
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Old October 18, 2003, 11:43   #9
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This is all very nice, But what is the true mechanism...
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Old October 18, 2003, 13:49   #10
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Stupid insomnia.
Stupid Fight Club.

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Old October 18, 2003, 15:57   #11
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This disease is bull****. When will scientists finally admit that the deaths are caused by Freddy Krueger?
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Old October 18, 2003, 19:32   #12
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Dude, that's not funny. I already have trouble sleeping without worrying that Robert Englund wearing latex and hedge trimmer gloves is going to visit me at night.
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Old October 18, 2003, 19:50   #13
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One, two - Freddy's coming for you...
Three, four - Better lock your door...
Five, six - Grab your crucifix...
Seven, eight - Gonna stay up late...
Nine, ten - Never sleep again...
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Old October 18, 2003, 19:54   #14
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I think I've got the cure for any Krueger situation that might arise.[img]http://wwwnew.towson.edu/honors/excelsior/Images/jason9.jpg
[/img]
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Old October 18, 2003, 20:07   #15
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Suicide? If you're dead, Freddy can't kill you.
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Old October 18, 2003, 20:18   #16
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no, this:

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Old October 18, 2003, 20:30   #17
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I thought Jason and Freddie already duked it out. I don't know who won, though.
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Old October 19, 2003, 08:39   #18
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Quote:
Originally posted by st_swithin
I already have trouble sleeping without worrying that Robert Englund wearing latex and hedge trimmer gloves is going to visit me at night.
Its not actually as bad as it sounds
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Old October 19, 2003, 08:56   #19
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Jason won.
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Old October 19, 2003, 08:58   #20
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Ah, yes, but Fredie was still very much alive at the end...or at least his disembodied head was.
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Old October 19, 2003, 09:12   #21
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Old October 19, 2003, 09:15   #22
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Old October 19, 2003, 09:32   #23
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Jason, Jason, Jason... *cheer*
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Old October 19, 2003, 09:40   #24
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Jason is just thick and violent. Where as Freddie on the other hand...a kind of charm/charisma similar to Hannibal. In Freddie vs Jason, he was just using Jason to kill people as part of his master plan.
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Old October 19, 2003, 11:40   #25
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A hockeymask wards off Freddy?
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Old October 19, 2003, 12:54   #26
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Quote:
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Quote:
I already have trouble sleeping without worrying that Robert Englund wearing latex and hedge trimmer gloves is going to visit me at night.
Its not actually as bad as it sounds
I don't carry a hedge trimmer that often Whatever do you mean dear?
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Old October 19, 2003, 15:10   #27
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moose.
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Old October 19, 2003, 17:11   #28
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Old October 19, 2003, 17:20   #29
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Quote:
Originally posted by Verres
Jason is just thick and violent. Where as Freddie on the other hand...a kind of charm/charisma similar to Hannibal. In Freddie vs Jason, he was just using Jason to kill people as part of his master plan.
which came back to bite him in the ass.

Personally, I feel sorry for jason, he's just a very troubled individual. He was damaged as a child.
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Old October 19, 2003, 18:19   #30
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Personally, I feel sorry for jason, he's just a very troubled individual. He was damaged as a child.
And Freddy wasn't? His mother was raped by a thousand lunatics...
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